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beijingkejidaxuesongyujuntuanduizaikangzhongliuduomonamiyaowushangqudexinchengguo

zuijin,zaichuanranbingfangzhiguojiakejizhongdazhuanxiang“yuanshichuangxinxingnamiaodaojingzhunxiaorongganaikangfufazhuanyideyanfajilinchuangyingyongyanjiu(2018zx10301201)”heguojiaziranjijinmianshangxiangmu“juyouduozhongcijixiangyingheduomochengxianggongnengkoufuxingganainamiyaowujiegoushejihezhibeijiyaoliyanjiu(51971029)”jiguojiazirankexuejijinweiguoji(diqu)hezuoyujiaoliuxiangmu(nsfc-brics)“juyougaociguangxiaoyinghezixuan-guidaoxianghuzuoyongdenamijiegou(51861145309)“dezizhuxia,beijingkejidaxuesongyujunjiaoshoulianhezhejiangdaxuechenxinhuajiaoshou、shamendaxueliwengangjiaoshou、hafodaxuedavid a. weitzjiaoshoudengtuandui,yanzhiduomoyingxianggongnengnamiyaowu,bingzaizhongliuzhiliaodeqianzaiyingyongfangmianqudexinchengguo。yanjiuchengguoyi“microfluidic synthesis of multi-mode au@cofeb-rg3 nanomedicines and their cytotoxicity and anti-tumor effects (quanwenlianjiehttp://pubs.acs.org/doi/10.1021/acs.chemmater.0c00797)” (duomoyingxianggongnengdeau @ cofeb-rg3namiyaowudeweiliutihechengjiqixibaoduxinghekangzhongliuxiaoguo)weiti,zaiguojizhumingqikanchemistry of materials(zhongkeyuanjcrfenqu1qu,2019nianyingxiangyinziwei 10.159)zaixianfabiao。beijingkejidaxuesongyujunjiaoshouweitongxunzuozhe,beijingkejidaxuezhangweiweiboshihezhaoxiaoxiongjihafodaxueyuanyuanboshiweigongtongdiyizuozhe。

songyujuntuanduitongguoxiandaiwulijishuyuyigongxinjiaochachuangxin,jiangzhongyaoyouxiaochengfenyuduomonamikelioulian,goujianleyizhongduomodexinxingnamiyaowu (tu1)。tamenbujinkeyitongguoanchangxianweijingjinxingguangxuejiance (tu2),keyitongguoxshexianjisuanjiduancengsaomiaochengxiang;haikeyiyongzuocigongzhenchengxiangzaoyingji,juyouchusedet2jiaquanzixuanhuibochengxiangxiaoguo。ciwaitaduirenganaixibaoherenmanxingsuixingbaixuebingxibaodezengzhibiaoxianchumingxiandexibaoduxingheyizhizuoyong,bingqiezaidinongduxiaduijurkat-ctxibaojihumeiyouduxing,shuomingzaiheshinongduxiajuyouhemianyixibaogaoxiangrongxing,zhanxianletayongzuoduomoyingxianggongnengnamitanzhenhemianyileiliaofaxiangrongdeqianzhi。zheixiefaxianweijiyuduomoshinamikelihezhongyaoyouxiaochengfenouliandeduogongnengkangzhongliunamiyaowudehechengtigongleyouxiaodefangfa,weifajuewoguozhongyiyaobaokudexiandaihuayingyongtigongleshili;zaichuanranbingfangzhiguojiakejizhongdazhuanxiang(2018zx10301201)heguojiaziranjijinmianshangxiangmu(51971029)zizhudeqianqihezuochengguoshang,tuanduilianhezhejiangdaxuechenxinhuatuanduidezuijinchengguo—yuanshichuangxinxingnamiaodaoxiaorongzhongliuliaofa,yijingkaishilehouxudenamiaodaolianhenamiyaowukangzhongliuyuanchuangxinglianheliaofadedongwushiyan,chubujieguoxianshiqijuyouxianzhudeyizhizhongliuxiaoguo,jutishujuzhengzaizhenglilunwendengdaifabiao。

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图1 通过硅烷激活偶联方法将Au@CoFeB与人参皂苷Rg3共轭制备的抗肿瘤纳米药物具有光学、磁共振和计算机辅助X-光断层扫描影像功能

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tu2 zhibeideduomoau@cofebnamiyaowugongerencanzaoganrg3qian(a)hou(b)dejuyubiaomiandenglizitigongzhensansheguangxuetuxiangheguangpu

ciqian,songyujuntuanduiyanzhidenamiyaowu“namitiegan(nano-fe-rg3)yitongguohezhejiangdaxueyixueyuanhezhengzhoudaxueyixueyuandengdanweihezuo,duiqikangganaixiaoguojinxingledongwuhuotishiyan,zaierjiajiyaxiaoanyoudaodeganaimoxingzhong,nano-fe-rg3deyingyongxianzhuyanzhangleganaixiaoshudecunhuoshijian,nano-fe-rg3deyingyongxianzhuyizhilehccdefazhan,bingxiaochulehccxiangfeidezhuanyi,chengguoyi” nanoparticle conjugation of ginsenoside rg3 inhibits hepatocellular carcinoma development and metastasis“weitiyifabiaozaiguojizhumingyingyongwulileiqikan(zhongkeyuanjcrfenqu1qu,2019nianyingxiangyinziwei 10.856)smallshang(yuanwenlianjie:http://doi.org/10.1002/smll.201905233)。tebieshi,namitiegandeyingyongyanchilehccyoudaodehuimangbuxingtaihechangdaoweishengwugaibianchaoguo12zhou,gaiyaokezengjialeiganjunheyouzhuangyabaojundefengdu,danjianshaoyingbijun。zainamitieganjiyaohou,29zhongyucedeweishengwujiyingongnengbeifuji,er7zhongjiyingongnengbeijiangdi。ciwai,daixiezuxuezaihccfazhanguochengzhongchengxianchuxianzhudejinzhan,dannamitieganjiyaojiuzhenglezhongliuzhudaodedaixiezuxue。namitieganjiyaojiangdile3-yinduobingsuanheniaosu,dantigaoleyoulizhifangsuan。zhongyaodeshi,namitiegandeyingyongzhongsulehcczhiliaoqijianchangdaoweishengwuquxihedaixiezhijianbupinghengdexiangguanwangluo。namitiegantongguozhongsutineibupinghengdechangdaojunqunhedaixielaiyizhiganaidefazhanhezhuanyi,tigongleyizhongkangzhongliuzhiliaocelve。ganxibaoai(hcc)shiquanqiudisandaaizhengxiangguansiwangyuanyin。hccdeyuhourengranhencha,yinci,youxiaodezhiliaorengshifeichangpoqiede。

lingwaigaileinamiyaowuduiaiwang”yixianai“dezhiliaoxiaoguodedongwushiyanyequdelexiaoguo,zaizhenglifabiaozhong。jiangnamikeliyuwoguochuantongzhongyaoyouxiaochengfenrencanzaoganrg3oulian(nprg3),kaifachuyizhongjuyoulianghaooulianxiaoguoheliaoxiaodekangzhongliunamiyaowu,kaipilenamiyaowuhenamizhongyaokangzhongliudexinlingyu。muqiangaichengguoyizainamiren、qiwulunherenminribaobaodao。

批注 2020-06-15 160553_副本.png

tu3namitiegan(nano-fe-rg3)bujinjuyoukangganaiheyizhizhongliuxibaofeizhuanyixiaoguo,duihccyoudaodehuimangbuxingtaihechangdaoweishengwuehuadezhongsuhaozhuanyeyoumingxianxiaoguo。

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